Cladribine for hairy cell leukemia

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Cladribine injection should be administered under the supervision of a qualified physician experienced in the use of antineoplastic therapy. Suppression of bone marrow function should be anticipated. This is usually reversible and appears to be dose dependent. Serious neurological toxicity including irreversible paraparesis and quadraparesis has been reported in patients who received cladribine injection by continuous infusion at high doses 4 to 9 times the recommended dose for Hairy Cell Leukemia. Neurologic toxicity appears to demonstrate a dose relationship; however, severe neurological toxicity has been reported rarely following treatment with standard cladribine dosing regimens.
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Cladribine

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Cladribine - National Cancer Institute

Note: patients who had complete response before 6 months were given 2 additional cycles of pentostatin, and then treatment was stopped. Patients with objective partial response after 6 months of treatment received an additional 6 months of additional therapy, until they had a complete response or progression of disease. Note: this was a dose-escalation study and the bendamustine dose was selected for further study based on absence of DLT. Note that a pooled analysis of two phase II trials is reported; they have slightly different durations - please see original text for details. Note: this is a distinct disease process from hairy cell leukemia, but will be included on this page for now given the similarities. We may create a dedicated page in the future.
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Cladribine Injection

Farhad Ravandi from the University of Texas-M. Anderson Cancer Center. Hairy cell leukemia is what we call an indolent, and that means generally very slow growing, lymphoid leukemia. Emphasis on lymphoid because it arises from within the lymphoid part of the compartment of bone marrow.
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The spleen is a small organ normally about the size of your fist. A number of conditions, including liver disease and some cancers, can cause your spleen to become enlarged. In a bone marrow aspiration, a doctor or nurse uses a thin needle to remove a small amount of liquid bone marrow, usually from a spot in the back of your hipbone pelvis. A bone marrow biopsy is often done at the same time.
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